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Steven E. Raper, M.D.
Gastrointestinal Surgery
 
Publications
   
Original Papers

Yee ES, Raper SE, Thomas AN, Ebert PA: Technical accuracy and clinical efficacy of thoracic computed tomography. Am J Surg 144:35-43, 1982.

Burwen SJ, Barker ME, Goldman IS, Hradek GT, Raper SE, Jones AL: Transport of epidermal growth factor by rat liver: Evidence of a non-lysosomal pathway. J Cell Biol 99:1259-1265, 1984.

Goldman IS, Winkler ML, Raper SE, Barker ME, Keung E, Goldberg HI, Boyer TD: Increased hepatic density and phospholipidosis due to amiodarone. Am J Roentgenol 144:541-546, 1985.

Duh QY, Gum ET, Gerend P, Raper SE, Clark OH: Epidermal growth factor receptors in normal and neoplastic thyroid tissue. Surgery 98:1000-1007, 1985.

Duh QY, Gum ET, Sancho JJ, Levin KE, Raper SE, Clark OH: Epidermal growth factor receptors in parathyroid tissue. J Surg Res 40:569-573, 1986.

Bresalier RS, Raper SE, Hujanen ES, Martin GR, Kim YS: A new animal model for human colon cancer metastasis. Int J Cancer 39:625-630, 1987.

Bresalier RS, Hujanen ES, Raper SE, Roll FJ, Itzkowitz SH, Martin GR, Kim YS: An animal model for colon cancer metastasis: establishment and characterization of cell lines with enhanced liver-metastasizing ability. Cancer Res 47:1398-1406, 1987.

Raper SE, Barker ME, Burwen SJ, Jones AL: Isoflurane as an anesthetic for experimental animal surgery. Anat Rec 218:116-122, 1987.

Raper SE, Burwen SJ, Barker ME, Jones AL: Translocation of epidermal growth factor to the hepatocyte nucleus during liver regeneration. Gastroenterology 92:1243-1250, 1987.

Eckhauser FE, Lloyd RV, Thompson NW, Raper SE, Vinik AI: Antrectomy for multicentric, argyrophil gastric carcinoids: a preliminary report. Surgery 104:1046-1053, 1988.

Eckhauser FE, Knol JA, Raper SE, Guice KS: Completion gastrectomy for postsurgical gastroparesis syndrome: preliminary results with 15 patients. Ann Surg 208:345-353, 1988.

Raper SE, Barker ME, Jones AL, Way LW: Anatomic correlates of bacterial cholangiovenous reflux. Surgery 105(3):352-359, 1989.

Pomerantz RA, Eckhauser FE, Knol JA, Guice K, Raper SE, Turcotte JG: Operative timing and patient survival following distal splenorenal shunt. Am Surg 55:333-337, 1989.

Pellegrini CA, Heck CF, Raper SE, Way LW: An analysis of the reduced morbidity and mortality rates after pancreatoduodenectomy. Arch Surg 124:778-781, 1989.

Eckhauser FE, Raper SE: Peptic ulcer disease, gastrointestinal hemorrhage and hypercalcemia: multiple endocrine neoplasia syndrome, type I: Postgrad Gen Surg 2(2):61-6, 1990.

Raper SE, Kothary PC, Kokudo N, DelValle J, Eckhauser FE: The liver plays an important role in the regulation of somatostatin-14 in the rat. Am J Surg 161:184-189, 1991.

Raper SE, Kothary PC, Kokudo N: Somatostatin-14 blocks the hepatotrophic effects of insulin in the rat. J Surg Res 50:386-390, 1991.

Eckhauser FE, Raper SE, Mulholland MW, Knol JA: Current concepts in the pathophysiology and treatment of portal hypertension and variceal hemorrhage. Gastroenterol Jpn 26(suppl 3):1-8, 1991.

Kokudo N, Eckhauser FE, Kothary PC, Raper SE: Inhibitory effects of somatostatin on rat hepatocyte proliferation are mediated by cyclic AMP. J Surg Res 51:113-118, 1991.

Eckhauser FE, Knol JA, Raper SE, Mulholland MW: A simplified and reliable method for transduodenal sphincteroplasty. Surg Rounds 14(7):595-599, 1991.

Eckhauser FE, Raper SE, Knol JA, Mulholland MW, et al: Extracorporeal lithotripsy: an important adjunct in the nonoperative management of retained or recurrent bile duct stones. Arch Surg 126:829-835, 1991.

Hirschl R, Eckhauser FE, Raper SE: Reconstruction of the abdominal wall by placement and early excision of prosthetic mesh. Surg Gynecol Obstet 173:237-238, 1991.

Guynn TP, Eckhauser FE, Knol JA, Raper SE, et al: Injection sclerotherapy-induced esophageal strictures: risk factors and prognosis. Am Surg 57(9):567-572, 1991.

Grossman M, Raper SE, Wilson JM: Towards liver-directed gene therapy: retrovirus-mediated gene transfer into human hepatocytes. Somatic Cell Mol Genet 17(6):601-607, 1991.

Kokudo N, Kothary PC, Eckhauser FE, Nakamura T, Raper SE: Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor. Am J Surg 163:169-173, 1992.

Eckhauser FE, Raper SE, Knol JA, Mulholland MW: Surgical management of pancreatic pseudocysts, pancreatic ascites, and pancreaticopleural fistulas. Pancreas 6(Suppl. 1):S66-S75, 1991.

Eckhauser FE, Knol JA, Raper SE, Mulholland MW, Helzerman P: Efficacy of two comparative antibiotic regimens in the treatment of serious intra-abdominal infections: results of a multicenter study. Clin Ther 14(1):97-109, 1992.

Raper SE, Eckhauser FE: Delayed gastric emptying after truncal vagotomy and gastrojejunostomy. Postgrad Gen Surg 4(3):214-216, 1992.

Wilson JM, Grossman M, Raper SE, Baker JR, Newton RS, and Thoene JG: Clinical Protocol: Ex vivo gene therapy of familial hypercholesterolemia. Human Gene Therapy 3:179-222, 1992.

Raper SE, Kothary PC, Del Valle J: Identification and partial characterization of a somatostatin-14 binding protein on rat liver plasma membranes. Hepatology 16(2):433-439, 1992.

Raper SE, Wilson JM, Grossman M: Retroviral-mediated gene transfer in human hepatocytes. Surgery 112:333-40, 1992.

Kokudo N, Kothary PC, Eckhauser FE, Raper SE: Transforming growth factor -? (TGF-?) improves hepatic DNA synthesis after hepatectomy in cirrhotic rats. J Surg Res 52:648-655, 1992.

Grossman M, Raper SE, Wilson JM: Transplantation of genetically-modified autologous hepatocytes into non-human primates: Feasibility and short-term toxicity. Hum Gene Ther 3:501-510, 1992.

Raper SE, Kothary PC, Kokudo N, Del Valle J: Hepatectomy impairs hepatic processing of somatostatin-14. Am J Surg 165(1):89-95, 1993.

Hashimoto M, Kothary PC, Raper SE: The effects of transforming growth factor alpha and somatostatin on the processing of liver regeneration in the rat. Regul Pept 44:49-59, 1993.

Grossman M, Wilson JM, Raper SE: A novel approach for introducing hepatocytes into the portal circulation. J Lab Clin Med 121:472-478, 1993.

Yang Y, Raper SE, Cohn JA, Engelhardt JF, Wilson JM: An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proc Natl Acad Sci 90:4601-4605, 1993.

Raper SE, Wilson JM: Cell transplantation in liver directed gene therapy. Cell Transplantation 2:381-400, 1993.

Thornton AJ, Bruzdzinski CJ, Raper SE and Gelehrter TD. Plasminogen activator inhibitor-1 (PAI-1) is an immediate early response gene in regenerating rat liver. Cancer Research 54:1337-1343 1994.

Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D and Wilson JM: Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nature Genetics 6:335-341, 1994.

Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM. In vivo correction of low density lipoprotein receptor deficiency in the watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. The Journal of Biological Chemistry 269:13695-13702 1994.

Eckhauser FE, Knol JA, Raper SE, Thompson NW. Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma. Am Surg 60:466-471 1993.

Bhora FY, Kothary PC, Imanishi H, Raper SE. Vasopressin stimulates DNA synthesis in cultured rat hepatocytes. Journal of Surgical Research 57:706-710, 1994.

DeMatteo RD, Markmann J, Raper SE. An improved technique of thymectomy in the adult mouse. Transplantation 59:787-789, 1995.

Imanishi H, Kothary PC, Bhora FY, Eckhauser FE, Raper SE. Impaired phorbol ester-induced hepatocyte proliferation in cirrhosis. J Surg Res. 58:435-440, 1995

Gerkin TM, Eckhauser FE, Raper SE, Mulholland MW, Knol JA, Schork MA. Are traditional prognostic criteria useful in pancreatic abscess? Pancreas 10:331-337, 1995.

Raper SE, Kothary P, Ishoo E, Dikin M, Kokudo N, Hashimoto M, DeMatteo RP. Divergent mechanisms of insulin-like growth factor I and II on rat hepatocyte DNA synthesis. Regulatory Peptides. 58:55-62, 1995

DeMatteo RP, Raper SE, Ahn M, Fisher KJ, Burke C, Widera G, Claytor B, Barker CF, Markmann JF. Gene transfer to the thymus: A means of abrogating the immune response to recombinant adenovirus. Ann Surg. 222:229-242, 1995

Grossman M, Rader DJ, Muller DWM, Kolansky DM, Kozarsky K, Clark BJ, Stein EA, Lupien PJ, Brewer HB, Raper SE, Wilson JM. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nature Medicine 1:1148-1154, 1995.

Kothary PC, Kokudo N, Raper SE: Preferential suppression of insulin-stimulated proliferation of cultured hepatocytes by somatostatin: Evidence for receptor-mediated growth regulation. J Cell Biochem. 59:258-265 1995.

Raper SE. Hepatocyte transplantation and gene therapy. Clinical Transplantation. 9:249-254; 1995.

DeMatteo RP, Markmann JF, Barker CF, Raper SE. Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Therapy. 3:4-12 1996.

Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ, Kolansky DM, Muller DWM, Wilson JM. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann Surg. 223:114-123; 1996

Raper SE, DeMatteo RP. Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Pancreas, 12:401-410; 1996

Cabrera JA, Wilson JM, Raper SE. Targeted retroviral gene transfer into the rat biliary tract. Som Cell Molec Genet. 22:21-29; 1996

Kucharchuk J, Raper S, Elshami A, Amin K, Sterman D, Wheeldon E, Wilson JM, Litzky L, Kaiser L, Albelda S. Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex virus thymidine kinase cDNA followed by ganciclovir in non-human primates. Human Gene Therapy. 7:2225-2233; 1996

Hamilton T, DeMatteo R, McClane S, Burke C, Rombeau J, Raper SE. Adenoviral-mediated gene transfer to murine small intestine is more efficient in neonates than adults. J Ped Surg. 32:373-377; 1997

Fisher KJ, Jooss K, Alston J. Yang Y, Haecker SE, Pathak R, Raper SE, Wilson JM. Recombinant adeno-associated virus for muscle-directed gene therapy. Nature Medicine. 3:306-312; 1997

McClane SJ, Hamilton TE, Burke CV Raper SE. Functional consequences of adenovirus-mediated murine pancreatic gene transfer. Human Gene Therapy. 8:739-746; 1997.

DeMatteo RP. Chu G. Ahn M. Chang E. Burke C. Raper SE. Barker CF. Markmann JF. Immunologic barriers to hepatic adenoviral gene therapy for transplantation. Transplantation. 63:315-9, 1997.

McClane S, Hamilton T, Burke C, Raper SE. The effect of adenoviral early genes and the host immune system on in vivo pancreatic gene transfer in the mouse. Pancreas. 15:236-245; 1997

Smith JG, Raper SE, Wheeldon E, Hackney D, Judy K, Wilson JM, Eck SL. Intracranial administration of adenovirus expressing HSVTK in combination with ganciclovir produces a dose dependent, self-limiting inflammatory response. Human Gene Therapy. 8:943-954; 1997

DeMatteo RP, McClane SJ, Fisher KJ, Yeh H, Chu G, Burke CV, Raper SE. Engineering tissue-specific expression of a recombinant adenovirus: Selective transgene transcription in the pancreas using the amylase promoter. J Surg Res. 72:155-161 1997

Hamilton TE, McClane S, Baldwin S, Burke CV, Patel H, Rombeau JL, Raper SE. Efficient adenoviral-mediated murine neonatal small intestinal gene transfer is dependent in ?v integrin expression. J Ped Surg. 32:1695-1703; 1997

McClane SJ, Chirmule N, Burke CV, Raper SE. Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Human Gene Therapy. 8:2207-2216, 1997.

Raper SE, Haskal ZJ, Ye X, Furth EE, Pugh C, Wilson JM. Selective gene transfer into the liver of non-human primates with E1-deleted, E2a defective, or E1-E4 deleted recombinant adenoviruses. Human Gene Therapy 9:671-679; 1998.

Chirmule N, Hughes JV, Gao G-P, Raper SE, Wilson JM. Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and non-human primate lungs. J Virol 72:6138-6145; 1998.

Raper SE, Wilson JM, Yudkoff M, Robinson MB, Ye X, Batshaw ML. Developing adenoviral-mediated in vivo gene therapy for ornithine transcarbamylase deficiency. J Inhert Metab Dis. 21S1:119-137; 1998

Ye X, Gao G-P, Pabin C, Raper SE, Wilson JM. Evaluating the Potential of Germline Transmission after Intravenous Administration of Recombinant Adenovirus in the C3H Mouse. Human Gene Therapy. 9(14):2135-2142, 1998

Hashimoto M, Kothary P, Raper SE. Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy. J Gastrol Hepatol. 13:1259-1265, 1998.

Hashimoto M, Kothary P, Raper SE. Phenobarbital in comparison with carbon tetrachloride and phenobarbital induced cirrhosis in rat liver regeneration. J Surg Res. 81:164-169, 1998.

DeMatteo RP, Yeh H, Friscia M, Capparelli D, Burke CV, Desai N, Chu G, Markmann JF, Raper SE, Barker CF. Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases. Ann Surg Onc 1999 Jan-Feb;6(1):88-94

Chirmule N, Truneh A, Haecker SE, Tazelaar J, Gao G-P, Raper SE, Hughes JV, Wilson JM. Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a non-depleting CD4 antibody. J. Immunol. 1999 Jul 1;163(1):448-55

Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE Cell biological assessment of human glucokinase mutants causing maturity onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinemia. Biochemical Journal. 342:345-352; 1999

Nunes, FA, Furth EE, Wilson JM, Raper, SE Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: Safety of readministration. Human Gene Therapy. 10:2515-2526; 1999.

Batshaw ML, Wilson JM, Raper SE, et al. Clinical Protocol: Recombinant adenovirus gene transfer in adults with partial ornithine transcarbamylase deficiency (OTCD). Human Gene Therapy 10:2419-2437; 1999

Raper SE. Acute pancreatitis secondary to dehydration: Case report and review of the literature. American Surgeon. American Surgeon 65:1084-1087; 1999

Chirmule N, Raper SE, Burkly L, Thomas D, Tazelaar J, Hughes JV, Wilson JM. Readministration of adenoviral vector in non-human primate lungs by blockade of CD-40-CD40L interactions. J Virol 74:3345-3352, 2000.

McCullough B, Yudkoff M, Batshaw ML, Wilson JM, Raper SE, Tuchman M. Genotype spectrum of ornithine transcarbamylase deficiency: Correlation with the clinical and biochemical phenotype. Am J Med Genet. 93:313-319; 2000.

Raper SE, Yudkoff M, Chirmule N, Gao G-P, Nunes F, Haskal ZJ, Furth EE, Propert K, Robinson MB, Magosin S, Simoes H, Speicher L, Hughes JV, Tazelaar J, Wivel NA, Wilson JM and Mark L. Batshaw ML A pilot study of in vivo liver directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. In press 4/01 Human Gene Therapy

Shifrin AL, Auricchio A, Yu Q-C, Wilson JM, Raper SE. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. In press 7/01 Gene Therapy.

Transaction and forum proceedings, Invited commentary, Letters to the Editor
Imanishi H, Kothary PC, Bhora F, Eckhauser F, Raper SE: TPA and vasopressin stimulate hepatic proliferation by PKC-dependent and -independent pathways. Surg Forum 23:157-159, 1993.

DeMatteo RD, Wilson JM, Raper SE: Optimization of pancreas-directed gene transfer in the rat. Surg Forum 45:127-129, 1994.

Min JK, Shaked A, Raper SE, Barker CF, Naji A. Adenoviral-mediated gene transfer of TGF-?1 and vIL-10 promotes long-term survival of islet allografts. Surgical Forum 46:438-440, 1995.

Hamilton TE, DeMatteo RP, Rombeau JL, Raper SE. A comparison of adenoviral and retroviral gene transfer into the small intestine. Surgical Forum 46:649-650, 1995.

Hamilton TE, Koide S, Zhang W, Rombeau JL, Raper SE. Adenoviral mediated gene transfer to the small intestinal isograft. Transplantation Proceedings. 28(5):2444, 1996

Raper SE. The four legged hepatocyte: Lessons learned about cholesterol metabolism from new technologies. Hepatology. 24:463-465; 1996.

Raper SE, Wilson JM. Making space for intestinal gene therapy. Gastroenterology. 112:1753-6, 1997.

Raper SE. Answering questions on a microscopic scale: The detection of circulating cancer cells. Surgery. 126:827-828; 1999

Shifrin AL, Auricchio A, Wilson JM, Raper SE. Correction of hyperglycemia by expression of insulin gene in the pancreas with adenoviral vector. Surg. Forum 51:47-49; 2000

Abstracts
Raper SE, Burwen SJ, Barker ME, Jones AL: Chloroquine inhibits epidermal growth factor (EGF) degradation. Clin Res 32:28A, 1984.

Raper SE, Barker ME, Jones AL: Structural and functional analysis of isoflurane treated rat liver. Anatomical Record 208:142A, 1984.

Raper SE, Barker ME, Burwen SJ, Jones AL: The intracellular distribution and fate of epidermal growth factor (EGF) are altered during liver regeneration. Gastroenterology 86:1216, 1984.

Jones AL, Burwen SJ, Barker ME, Raper SE: DNA induction in bile duct epithelial and hepatic parenchymal cells following cholestasis in the rat: A possible role for epidermal growth factor. Hepatology 4:1029, 1984.

Bresalier RS, Raper SE, Kim YS: A new animal model for human colon cancer metastasis. Gastroenterology 88:1334, 1985.

Raper SE, Wong A, Barker ME, Jones AL, Way LW: Pathophysiology of bacterial cholangitis. Gastroenterology 88:1686, 1985.

Raper SE, Wang RA, Boyer TD, Jones AL: Isoflurane/O2 is a better experimental anesthetic than diethylether or pentobarbital: Experimental evidence. Gastroenterology 88:1686, 1985.

Raper SE, Burwen SJ, Barker ME, Jones AL: Intact epidermal growth factor (EGF) is translocated to the nucleus during liver regeneration. J Cell Biol 101:351A, 1985.

Bresalier RS, Toribara NW, Weiner HL, Raper SE, Swain JL, Kim YS: Angiogenin messenger RNA levels are related to degree of cell replication and differentiation in the regenerating rat liver and in human colon cancer cells. Gastroenterology 94:A48, 1988.

Raper SE, Kothary P, DelValle J: Somatostatin binding to rat liver plasma membranes. Gastroenterology 96:A408, 1989.

Kothary PC, DelValle J, Raper SE: Characterization of somatostatin receptor on liver plasma membrane. Presented at the American Society for Pharmacology and Experimental Therapeutics, 1989.

Lin T, Raper SE: Hepatic somatostatin uptake after 70% hepatectomy. Clin Res 37(4), 1989.

Raper SE, Kothary PC: Uptake and biliary secretion of somatostatin-14 in normal and regenerating rat liver. Hepatology 10(4), 1989.

Kothary PC, DelValle J, Raper SE: Characterization of somatostatin receptors on liver plasma membrane. The Pharmacologist 31:148, 1989.

Kokudo N, Raper SE, Kothary PC, Eckhauser FE: The inhibitory effect of somatostatin on rat hepatocyte proliferation is mediated by cyclic AMP. Presented at the Association for Academic Surgery, November 1990.

Raper SE, Kothary PC, Kokudo N, Delvalle J: Somatostatin transport in rat liver: Dependence on Microtubules. Presented at the Moses Gunn Annual Research Conference, Ann Arbor, MI, May 1991.

Kothary PC, Kokudo N, Raper SE: Differential effect of somatostatin (SS-14) on thymidine uptake by hepatocytes in culture from intact and regenerating rat liver. J Neurochem Vol. 57, Suppl 1991.

Raper SE, Kothary PC, Kokudo N: Lack of somatostatin effect on regenerating hepatocytes: Evidence for growth regulation. Hepatology.

Thornton AJ, Bruzdzinski CJ, Raper SE, Gelehrter TD: Plasminogen activator inhibitor-1 is an immediate early response gene expressed during liver regeneration. XI International Congress of Fibrinolysis 6 (Suppl 2):19, 1992.

Kothary PC, Kokudo N, Raper SE: Pertussis toxin (PT) blocks cAMP dependent and independent actions of somatostatin (SS-14). V International Congress on Cell Biology P-7.3, no. 65:214, 1992.

Raper SE, Yang Y, Wilson JM: Development of a rat model for adenovirus-mediated gene transfer into the pancreas. J Cell Biochem (Suppl) 17E no. SZ 322, 1993

Raper SE, Kothary P, Ishoo E, Dikin M, Kokudo N, Eckhauser FE, Hashimoto M: Divergent mechanisms of insulin-like growth factor I and II on hepatocyte proliferation. Society for Surgery of the Alimentary Tract, Annual Meeting, May 1993.

Kothary P, Kokudo N, Hashimoto M, Eckhauser F, Raper S: Molecular and functional characterization of the inhibitory G-protein Gi in CCI4 induced cirrhotic rats. Society for Surgery of the Alimentary Tract, Annual Meeting, May 1993.

Raper SE, Yiping Y, Wilson JM: Development of a rat model for adenovirus-mediated gene transfer into the pancreas. Presented at the Moses Gunn Annual Research Conference, Ann Arbor, MI, May 1993.

DeMatteo RP, Markmann JF, Wilson JM, Raper SE. Prolonged adenoviral transgene expression in mouse liver using T-lymphocyte subset depletion. Gene Therapy, Cold Spring Harbor Laboratory, Long Island New York, September 1994

Raper SE, Campos L, Min J, Naji A. Functional Analysis Of Rat Islets Of Langerhans Infected With Recombinant Adenoviruses. Gene Therapy, Cold Spring Harbor Laboratory, Long Island New York, September 1994

Burke CV, Raper SE. Production of Recombinant Adenoviruses for Analysis Of Glucose Metabolism in Islets Of Langerhans. 1994 Institute for Human Gene Therapy Retreat, Absecon, New Jersey, October 1994

McClane SJ, Burke CV, Raper SE. The Development And Use Of Recombinant Adenovirus Containing The Mouse Cytoplasmic And Mitochondrial Glycerol-3-Phosphate Dehydrogenase Gene In Vitro. 1995 Institute for Human Gene Therapy Retreat, Absecon, New Jersey, October 1995

Nunes F, Raper S, Wilson J. Readministration of recombinant adenovirus in the rhesus monkey. Gastroenterology 1996.

McClane SJ, Burke C, Raper SE. The molecular cloning and construction of a recombinant adenovirus containing the mouse cytoplasmic glycerol-3-phosphate dehydrogenase gene. Pancreas Club, San Franscisco, CA 5/19/96.

Raper SE, Burke C, McClane SJ. Construction and functional characterization of a recombinant adenovirus expressing rat glucokinase. Pancreas Club, San Franscisco, CA 5/19/96.

Chirmule N, Raper SE, Hess D, Thomas DW, Wilson JM. CD40-CD40L interactions are critical in immune responses to adenoviral vectors in non-human primates. AAAAI/AAI/CIS joint meeting. Feb 22 1997.

Raper SE, Batshaw ML, Ye X, Gao G-P, Wilson JM. Comparative toxicity of E4 deleted vectors expressing human ornithine transcarbamylase (OTC) cDNA. American Pediatric Society Annual Meeting, New Orleans, LA. May 4, 1998

Raper SE, Batshaw ML, Ye X, Gao G-P, Wilson JM. Phase I trial of adenoviral gene transfer in ornithine transcarbamylase deficiency. American Pediatric Society Annual Meeting, New Orleans, LA. May 4, 1998

Raper SE, Batshaw ML, Ye X, Gao G-P, Wilson JM. Comparative toxicity of E4 deleted vectors expressing human ornithine transcarbamylase (OTC) cDNA. American Society of Gene Therapy Annual Meeting, Seattle, WA. May 28, 1998

Raper SE, Batshaw ML, Ye X, Gao G-P, Wilson JM. Phase I trial of adenoviral gene transfer in ornithine transcarbamylase deficiency. American Society of Gene Therapy Annual Meeting, Seattle, WA., May 29, 1998

Auricchio A, Gao GP, Zoltick P, Shifrin A, Raper SE, Rivera V, Wilson JM. Regulated insulin gene delivery for treatment of type I diabetes. Molecular Therapy 1(5):S293; 2000

Shifrin AL, Chirmule N, Chapman K, Raper SE. Innate immune response to adenoviral vector-mediated pancreatitis. J Surg Res. 93:359-360; 2000

Editorials, Reviews, Chapters
Way LW, Raper SE. Jaundice, in Davis JM, et al (eds) Clinical Surgery. CV Mosby, St Louis, MO, 1987.

Eckhauser FE, Raper SE. Endoscopic treatment of esophageal varices and transjugular intrahepatic portosystemic shunts. in GD Zuidema (ed) Surgery of the Alimentary Tract. WB Saunders and Co, Philadelphia, PA, 4th edition, 1995, Volume III pp.

Eckhauser FE, Raper SE, Knol JA, Turcotte JG. Esophageal Varices, in GD Zuidema (ed) Surgery of the Alimentary Tract. WB Saunders and Co, Philadelphia, PA, 4th edition, 1995, Volume I, pp 369-386.

Knol JA, Raper SE, Eckhauser FE. Biliary Fistulas, in GD Zuidema (ed) Surgery of the Alimentary Tract. WB Saunders and Co, Philadelphia, PA, 4th edition, 1995, Volume III, pp 249-254.

Eckhauser FE, Knol JA, Raper SE, Mulholland MW. Variceal ligation and gastroesophageal devascularization for variceal hemorrhage, in Stanley JC (ed) Current Therapy in Vascular Surgery. Mosby-Year Book Inc, St Louis, MO, 2nd edition, 1991, pp 793-796.

Barnett JL, Raper SE. Anorectal diseases, in Yamada T (ed) Atlas of Gastroenterology. JB Lippincott, Philadelphia, PA, 1991, pp 1813-1835.

Eckhauser FE, Raper SE, Knol JA. Upper gastrointestinal bleeding, in Schwartz GR, Cayten CG, Mangelsen MA, Mayer TA, Hanke BK (eds) Principles and Practice of Emergency Medicine. Lea & Febiger, Philadelphia, PA, 3rd edition, 1992, pp 1735-1744.

Eckhauser FE, Raper SE. Diverticular disease of the small bowel, in Cameron JL (ed) Current Surgical Therapy. Mosby-Year Book Inc, St. Louis, MO, 4th edition, 1992, pp 123-127.

Raper SE. Hepatic physiology, in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB (eds) Surgery: Scientific Principles and Practice. JB Lippincott Co, Philadelphia, PA, 1992, pp 850-865.

Turcotte JG, Raper SE, Eckhauser FE. Portal hypertension, in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB (eds) Surgery: Scientific Principles and Practice. JB Lippincott Co, Philadelphia, PA, 1992, pp 887-908.

Eckhauser FE, Raper SE, Mulholland MW, Knol JA. Carcinoma of the gallbladder, in Niederhuber JE (ed) Current Therapy in Oncology. Mosby-Year Book Inc, St Louis, MO, 1993, pp 402-409.

Raper SE. Hepatobiliary Disease, Bongard FS, Sue DY (eds) in Critical Care Diagnosis & Treatment. Appleton & Large, 1994, pp 576-591.

Raper SE. Liver-directed gene therapy for metabolic disease. in S. Rosenberg ed. Volume 5: Gene Therapy in Surgery ; Proceedings from the 1993 Surgical Research and Education Symposium. Surgical Research & Education Committee, American College of Surgeons, Chicago, IL. 1994 pp 25-36.

Raper SE. Neoplastic disease of the small intestine. in Bell RH, Rikkers L, Mulholland MW. (eds) Digestive tract surgery: A text and atlas. JB Lippincott Co. 1995

Raper SE, and Wilson JM. Chapter 8: Gene therapy for human liver disease. in Progress in Liver Diseases . Boyer JL, Ockner RK eds. Vol. XIII:201-230; 1995

Rader D, Raper SE, Wilson JM. Chapter 46. Gene therapy for metabolic disease. In diabetes mellitus: A fundamental and clinical text. LeRoith D, Taylor SI, Olefsky JM. eds. Lippincott-Raven Philadelphia PA 1996.

Nunes F, Raper SE. Liver gene therapy. Med Clin North America. 80:1201-1214; 1996.

Raper SE. Human Gene Therapy, in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds) Surgery: Scientific Principles and Practice. JB Lippincott Co, Philadelphia, PA. 1996

Raper SE. Chapter 35 Hepatic physiology, in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K (eds) Surgery: Scientific Principles and Practice. (1st, 2nd, and) 3rd Ed. JB Lippincott Co, Philadelphia, PA, 2001.

Turcotte JG, Raper SE, Eckhauser FE. Portal hypertension, in Greenfield LJ, Mulholland MW, Oldham KT, Zelenock GB, Lillemoe K. (eds) Surgery: Scientific Principles and Practice. 1st and 2nd Ed. JB Lippincott Co, Philadelphia, PA, 1996

McClane SJ, Raper SE. Chapter 20: Liver Directed Gene Therapy. , in Mito M, Sawa M eds. Hepatocyte Transplantation. Karger Landes Systems. Basel Switzerland. 1998

Raper SE, Moscioni AD. Chapter 29: Ex vivo hepatocyte-directed gene therapy. In Berry MN Edwards AM eds. The Hepatocyte Review. Kluwer Academic Publishers. Dordrecht The Netherlands. 2000.

Books and Monographs
Andersen DA, Raper SE, Messina L, Economou JS Eds. Volume VI: Advances in Surgical Gene Therapy; Master Series in Surgery. World Medical Press. Cedar Knolls, NJ 1995

 


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