Reynold A. Panettieri, Jr, M.D.

Robert L. Mayock and David A. Cooper Professor of Medicine
Director, Airways Biology Initiative
Adjunct Professor, Wistar Institute

University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3403
tel.: (215)573-9860
fax: (215) 746-1224
email: rap@mail.med.upenn.edu

Education:

MD: University of Pennsylvania

Residency: Hospital of the University of Pennsylvania

Fellowship: Hospital of the University of Pennsylvania

Dr. Panettieri directs the Airways Biology Initiative at the University of Pennsylvania. His interests are in the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in subjects with chronic severe asthma. Dr. Panettieri's lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte function.

In parallel with his basic science interests, Dr. Panettieri currently directs the comprehensive clinical program for the care of patients with asthma and is actively involved in clinical investigations focused on the management of asthma and COPD.

In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the Lung Cellular, Molecular, and Immunobiology Study Section of NIH and is a member of the American Society for Clinical Investigation and Association of American Physicians.

Cooper PR, Kajekar R, Lamb R, San Mateo L, Hornby PJ, Panettieri Jr RA: TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation. Am J Physiol-Lung Cell Mol Physiol, in press, PMID 19542247.

Damera ., Zhao H, Wang M, Smith M, Kirby C, Jester WF, Lawson JA, Panettieri Jr RA: Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells. Am J Physiol-Lung Cell Mol Physiol 296:L674-L683, 2009.

Damera G, Fogle HW, Lim P, Goncharova EA, Zhao H, Banerjee A, Tliba O, Krymskaya VP, Panettieri Jr RA: Vitamin D inhibits human airway smooth muscle growth through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br J Pharmacol, in press.

Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri Jr RA, Krymskaya VP: STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells:  Relevance to pulmonary LAM. Mol Pharmacol, in press, PMID 19596836.

Cohen ED, Ihida-Stansbury K, Lu MM, Panettieri Jr RA, Jones PL, Morrisey EE: Wnt signaling regulates smooth muscle precursor development in the lung via a tenascin-C/platelet derived growth factor receptor pathway. J Clin Invest, in press.

Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri Jr RA, Haczku A: Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. J Immunol 182:7888-7896, 2009.

Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado YS, Panettieri Jr RA, Tliba O: Vitamin D and glucocorticoids differentially modulate chemokine expression in airway smooth muscle cells. Br J Pharmacol 155:84-92, 2008.

Panettieri Jr RA: Asthma persistence versus progression: Does airway smooth muscle function predict irreversible airflow obstruction? Allergy Asthma Proc 30:103-108, 2009.

Tliba O, Panettieri Jr RA: Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol 71:509-535, 2009.

Amrani Y, Tliba O, Panettieri Jr RA: Biology of airway smooth muscle cells (Chapter 25), in Adkinson Jr NF, Bochner BS, Busse WW, Holgate ST, Lemanske Jr RF, Simons FER (Eds) Middleton’s Allergy: Principles and Practice, 7th Edition, Mosby/Elsevier Ltd, London, UK, pp 399-411, 2009.

Panettieri Jr RA, Kotlikoff MI, Gerthoffer WT, Hershenson MB, Woodruff PG, Hall IP, Banks-Schlegel S: Airway smooth muscle in bronchial tone, inflammation and remodeling: basic knowledge to clinical relevance.  Am J Respir Crit Care Med 177:248-252, 2008.