Horace DeLisser, M.D.

Associate Professor of Medicine

University of Pennsylvania Medical Center
Pulmonary, Allergy & Critical Care Division
SVM-Hill Pavilion, Room 410B
380 South University Avenue
Philadelphia, PA 19104-4539

email: delisser@mail.med.upenn.edu

Education:

MD: University of Pennsylvania

Residency: Hospital of the University of Pennsylvania

Fellowship: Hospital of the University of Pennsylvania

The theme of Dr. DeLisser's research is leukocyte-endothelial and endothelial-endothelial cell interactions. Specific projects involve studies on the structure function relationships of the platelet endothelial cell adhesion molecule (PECAM-1), leukocyte recruitment into inflammatory sites and the role of cell adhesion molecules in angiogenesis.

Dr. DeLisser's clinical interests include chronic pulmonary vascular disease and chronic interstitial lung disease, as well as medical ethics. Dr. DeLisser is married to Opal DeLisser, a critical care nurse and has two sons, Jason and Horace Jr.

Rolaki A, Coukos G, Loutradis D, Delisser HM, Coutifaris C, Makrigiannakis A. Luteogenic Hormones Act through a Vascular Endothelial Growth Factor-Dependent Mechanism to Up-Regulate {alpha}5{beta}1 and {alpha}v{beta}3 Integrins, Promoting the Migration and Survival of Human Luteinized Granulosa Cells. Am J Pathol. 170:1561-72, 2007

Slevin M., Krupinski J., Gaffney J., Matou S., West D., Delisser H.M., Savani R.C., Kumar S. Hyaluronan-mediated angiogenesis in vascular disease: Uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol. 26:58-68, 2007.

Cao, G., Savani, R.C., Fehrenbach, M., Lyons, C., Zhang, L., Coukos, G., DeLisser, H.M. Involvement of Endothelial CD44 During in Vivo Angiogenesis. Am. J. Path 169:325-336, 2006.

DeLisser, H.M., Helmke, BP., Cao, G., Egan, P., Taichman, D., Fehrenbach, M., Zaman, A., Cui, Z., Mohan, G., Baldwin, HS., Davies, PF, Savani, RC.: Loss of PECAM-1 Function Alveolarization, J. Biol. Chem, 281:8724-8731, 2006.

Tzima, E., Irani-Tehrani, M., Kiosses, W.B., Dejana, E, Shultz, D.A., Engelhardt, B., Cao, G., DeLisser, H.M., and Schwatz, M.A. A Mechanosensory Complex that Mediates the Endothelial Response to Fluid Shear Stress. Nature 437:426-431, 2005.

Zamon A., Cui, Z., Foley, J., Zhao, H., Grimm, P., DeLisser, H.M., and Savani, R.C. Role of the Hyaluronan Receptor RHAMM in Inflammation after Bleomycin-induced Lung Injury. Am. J. Resp. Cell Mol. Biol. 33:447-454, 2005.